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Compound Detail

CHEMBL333368

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O=C(Nc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1)c1cccnc1

Basic Information

ChEMBL ID CHEMBL333368
Phase Preclinical
Structure Type MOL
InChI Key RXAHNSAFOCJMJJ-FIRIVFDPSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

623.2
MW (Da)
4.08
ALogP
6
HBA
3
HBD
106.7
PSA (Ų)
0.27
QED
1
Ro5 Violations
8
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C35H35ClN6O3
MW 623.16
Aromatic Rings 4
Heavy Atoms 45
NP-Likeness -1.09

Activity Summary

EC50 1 meas. best 5.96

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Melanocortin receptor 4
CHEMBL259
EC50 5.96 5.96 1100.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Melanocortin receptor 4 EC50 = 1100.0 nM 5.96 Agonistic activity measured as inhibition of cAMP accumulation in HEK cells expr... 14552781

Literature References

PubMed DOI Target Context # Activities
14552781 10.1016/s0960-894x(03)00796-0 Melanocortin receptor 4 2

Data from ChEMBL 36 via Core Engine