Assay Detail
Functional
CHEMBL718153
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Compound was evaluated in vivo for its inhibitory activity against MRP1-transfected HL60/Adr cell line in mice
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | HL60/Adr |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Tricyclic isoxazoles are novel inhibitors of the multidrug resistance protein (MRP1).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.80 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL172119 | — | — | 1 | 7.16 |
| CHEMBL434490 | — | — | 1 | 6.80 |
| CHEMBL354935 | — | — | 1 | 6.72 |
| CHEMBL168831 | — | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL172119 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL434490 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL354935 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL168831 | — | EC50 | = | 320.0 | nM | 6.50 |