Assay Detail
Functional
CHEMBL718205
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro antagonist activity at recombinant human Metabotropic glutamate receptor 2 expressed in RGT cells.
22
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | RGT |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and metabotropic glutamate receptor antagonist activity of N1-substituted analogs of 2R,4R-4-aminopyrrolidine-2,4-dicarboxylic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 4.36 | 4.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL302411 | — | — | 1 | 4.70 |
| CHEMBL293434 | — | — | 2 | 4.44 |
| CHEMBL304919 | — | — | 1 | 4.43 |
| CHEMBL60164 | — | — | 1 | 4.38 |
| CHEMBL418650 | — | — | 1 | 4.33 |
| CHEMBL61281 | — | — | 1 | 4.30 |
| CHEMBL39338 | — | — | 1 | 4.30 |
| CHEMBL292553 | — | — | 1 | 4.21 |
| CHEMBL418462 | — | — | 1 | 4.12 |
| CHEMBL59830 | — | — | 1 | - |
| CHEMBL300330 | — | — | 1 | - |
| CHEMBL60008 | — | — | 1 | - |
| CHEMBL59920 | — | — | 1 | - |
| CHEMBL58247 | — | — | 1 | - |
| CHEMBL61964 | — | — | 1 | - |
| CHEMBL1169414 | — | — | 1 | - |
| CHEMBL304034 | — | — | 1 | - |
| CHEMBL406215 | — | — | 1 | - |
| CHEMBL60238 | — | — | 2 | - |
| CHEMBL60302 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL302411 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL293434 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL304919 | — | IC50 | = | 37300.0 | nM | 4.43 |
| CHEMBL60164 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL418650 | — | IC50 | = | 46200.0 | nM | 4.33 |
| CHEMBL61281 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL39338 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL292553 | — | IC50 | = | 61000.0 | nM | 4.21 |
| CHEMBL418462 | — | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL59830 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL293434 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL300330 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL60008 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL59920 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL60238 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL58247 | — | IC50 | = | 339000.0 | nM | - |
| CHEMBL61964 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL1169414 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL304034 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL406215 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL60238 | — | IC50 | = | 121000.0 | nM | - |
| CHEMBL60302 | — | IC50 | > | 300000.0 | nM | - |