Compound Detail
CHEMBL304919
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Basic Information
| ChEMBL ID | CHEMBL304919 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KWABXRJYGGENTG-YLJYHZDGSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
354.4
MW (Da)
1.76
ALogP
4
HBA
3
HBD
103.9
PSA (Ų)
0.73
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 4.43
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Metabotropic glutamate receptor 2 CHEMBL5137 | IC50 | 4.43 | 4.43 | 37300.0 | 1 |
| Metabotropic glutamate receptor 3 CHEMBL2888 | IC50 | 4.2 | 4.2 | 63600.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Metabotropic glutamate receptor 2 | IC50 | = | 37300.0 | nM | 4.43 | In vitro antagonist activity at recombinant human Metabotropic glutamate recepto... | 9873471 |
| Metabotropic glutamate receptor 3 | IC50 | = | 63600.0 | nM | 4.2 | In vitro antagonist activity at recombinant human Metabotropic glutamate recepto... | 9873471 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 9873471 | 10.1016/s0960-894x(98)00352-7 | Metabotropic glutamate receptor 1 | 1 |
| 9873471 | 10.1016/s0960-894x(98)00352-7 | Metabotropic glutamate receptor 5 | 1 |
| 9873471 | 10.1016/s0960-894x(98)00352-7 | Metabotropic glutamate receptor 2 | 1 |
| 9873471 | 10.1016/s0960-894x(98)00352-7 | Metabotropic glutamate receptor 3 | 1 |
| 9873471 | 10.1016/s0960-894x(98)00352-7 | Metabotropic glutamate receptor 4 | 1 |
| 9873471 | 10.1016/s0960-894x(98)00352-7 | Metabotropic glutamate receptor 8 | 1 |
Data from ChEMBL 36 via Core Engine