Assay Detail
Functional
CHEMBL718350
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 3
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RGT |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
2-substituted (2SR)-2-amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl)glycines as potent and selective antagonists of group II metabotropic glutamate receptors. 2. Effects of aromatic substitution, pharmacological characterization, and bioavailability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.82 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL432038 | — | — | 1 | 8.00 |
| CHEMBL124501 | — | — | 1 | 7.10 |
| CHEMBL2112634 | — | — | 1 | 7.10 |
| CHEMBL341457 | — | — | 1 | 6.80 |
| CHEMBL124078 | — | — | 1 | 6.77 |
| CHEMBL333771 | — | — | 1 | 6.75 |
| CHEMBL2111822 | — | — | 1 | 6.75 |
| CHEMBL123842 | — | — | 1 | 6.70 |
| CHEMBL338282 | — | — | 1 | 6.68 |
| CHEMBL124483 | — | — | 1 | 6.58 |
| CHEMBL123847 | — | — | 1 | 6.38 |
| CHEMBL2112582 | — | — | 1 | 6.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL432038 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL124501 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL2112634 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL341457 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL124078 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL333771 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL2111822 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL123842 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL338282 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL124483 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL123847 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL2112582 | — | IC50 | = | 650.0 | nM | 6.19 |