Compound Detail
CHEMBL2111822
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Basic Information
| ChEMBL ID | CHEMBL2111822 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BJKORSSOJCZBCJ-CIDASEACSA-N |
| Parent Compound | CHEMBL338911 |
| Active Moiety | CHEMBL338911 |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
341.4
MW (Da)
0.53
ALogP
5
HBA
3
HBD
134.8
PSA (Ų)
0.66
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 6.96
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 6.96 | 6.96 | 110.0 | 1 |
| Metabotropic glutamate receptor 3 CHEMBL2888 | IC50 | 6.75 | 6.75 | 180.0 | 1 |
| Metabotropic glutamate receptor 2 CHEMBL5137 | IC50 | 6.72 | 6.72 | 190.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 110.0 | nM | 6.96 | Binding affinity for Group II Metabotropic glutamate receptor was measured using... | 9464367 |
| Metabotropic glutamate receptor 3 | IC50 | = | 180.0 | nM | 6.75 | Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RG... | 9464367 |
| Metabotropic glutamate receptor 2 | IC50 | = | 190.0 | nM | 6.72 | Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RG... | 9464367 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 9464367 | 10.1021/jm970498o | Unchecked | 1 |
| 9464367 | 10.1021/jm970498o | Metabotropic glutamate receptor 2 | 1 |
| 9464367 | 10.1021/jm970498o | Metabotropic glutamate receptor 3 | 1 |
Data from ChEMBL 36 via Core Engine