Assay Detail
Binding
CHEMBL718943
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against human Melatonin receptor type 1B (MT2)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of a novel series of tricyclic indan derivatives as melatonin receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 10.03 | 10.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1218 | RAMELTEON | 4.0 | 1 | 10.35 |
| CHEMBL45 | MELATONIN | 4.0 | 1 | 9.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1218 | RAMELTEON | Ki | = | 0.045 | nM | 10.35 |
| CHEMBL45 | MELATONIN | Ki | = | 0.195 | nM | 9.71 |