Assay Detail
Binding
CHEMBL719079
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of binding to rat mGluR1a (metabotropic glutamate receptor) expressed in HEK-293 cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Metabotropic glutamate receptor 1 (CHEMBL4477) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Common and selective molecular determinants involved in metabotopic glutamate receptor agonist activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.01 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279956 | QUISQUALATE | — | 1 | 8.00 |
| CHEMBL575060 | GLUTAMIC ACID | 3.0 | 1 | 6.47 |
| CHEMBL39221 | — | — | 1 | 6.05 |
| CHEMBL94990 | — | — | 1 | 5.43 |
| CHEMBL284193 | — | — | 1 | 4.11 |
| CHEMBL33567 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279956 | QUISQUALATE | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL575060 | GLUTAMIC ACID | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL39221 | — | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL94990 | — | Ki | = | 3700.0 | nM | 5.43 |
| CHEMBL284193 | — | Ki | = | 77000.0 | nM | 4.11 |
| CHEMBL33567 | — | Ki | > | 1000000.0 | nM | - |