Assay Detail
Binding
CHEMBL719084
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Concentration for half maximal activation of metabotropic glutamate mGluR1a in rat
10
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Metabotropic glutamate receptor 1 (CHEMBL4477) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Metabotropic glutamate receptors: novel targets for drug development.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 5.19 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279956 | QUISQUALATE | — | 2 | 6.70 |
| CHEMBL30285 | IBOTENIC ACID | — | 2 | 5.22 |
| CHEMBL575060 | GLUTAMIC ACID | 3.0 | 2 | 5.05 |
| CHEMBL34453 | — | — | 3 | 4.66 |
| CHEMBL284193 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279956 | QUISQUALATE | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL279956 | QUISQUALATE | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL30285 | IBOTENIC ACID | EC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL575060 | GLUTAMIC ACID | EC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL575060 | GLUTAMIC ACID | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL34453 | — | EC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL30285 | IBOTENIC ACID | EC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL34453 | — | EC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL34453 | — | EC50 | = | 380000.0 | nM | - |
| CHEMBL284193 | — | EC50 | > | 1000000.0 | nM | - |