Assay Detail
Binding
CHEMBL729131
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Dissociation constant for binding to mitochondrial 12S rRNA construct M4 was determined
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Decoding region bubble size and aminoglycoside antibiotic binding.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 5.10 | 5.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1747 | TOBRAMYCIN | 4.0 | 1 | 5.54 |
| CHEMBL370143 | PAROMOMYCIN | 4.0 | 1 | 4.90 |
| CHEMBL1384 | KANAMYCIN | 4.0 | 1 | 4.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1747 | TOBRAMYCIN | Kd | = | 2910.0 | nM | 5.54 |
| CHEMBL370143 | PAROMOMYCIN | Kd | = | 12600.0 | nM | 4.90 |
| CHEMBL1384 | KANAMYCIN | Kd | = | 13600.0 | nM | 4.87 |