Assay Detail
Binding
CHEMBL731497
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Inhibitory activity against Mitogen-activated protein kinase p38 alpha 2
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and pharmacological characterization of a potent, orally active p38 kinase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 7.05 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL41723 | — | — | 1 | 7.89 |
| CHEMBL10 | SB-203580 | — | 1 | 7.70 |
| CHEMBL41310 | — | — | 1 | 7.48 |
| CHEMBL290971 | — | — | 1 | 7.46 |
| CHEMBL415679 | — | — | 1 | 7.43 |
| CHEMBL290982 | — | — | 1 | 7.42 |
| CHEMBL288812 | — | — | 1 | 7.38 |
| CHEMBL40138 | — | — | 1 | 7.36 |
| CHEMBL40166 | — | — | 1 | 7.35 |
| CHEMBL41653 | — | — | 1 | 7.28 |
| CHEMBL288663 | — | — | 1 | 7.27 |
| CHEMBL288891 | — | — | 1 | 7.24 |
| CHEMBL38548 | — | — | 1 | 7.16 |
| CHEMBL288889 | — | — | 1 | 7.16 |
| CHEMBL416425 | — | — | 1 | 7.16 |
| CHEMBL38625 | — | — | 1 | 7.06 |
| CHEMBL38084 | — | — | 1 | 6.96 |
| CHEMBL37353 | — | — | 1 | 6.85 |
| CHEMBL39251 | — | — | 1 | 6.80 |
| CHEMBL289056 | — | — | 1 | 6.74 |
| CHEMBL40020 | — | — | 1 | 6.70 |
| CHEMBL289155 | — | — | 1 | 6.63 |
| CHEMBL39136 | — | — | 1 | 6.58 |
| CHEMBL41970 | — | — | 1 | 6.57 |
| CHEMBL39931 | — | — | 1 | 6.54 |
| CHEMBL41266 | — | — | 1 | 6.51 |
| CHEMBL289357 | — | — | 1 | 6.38 |
| CHEMBL38648 | — | — | 1 | 6.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL41723 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL10 | SB-203580 | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL41310 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL290971 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL415679 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL290982 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL288812 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL40138 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL40166 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL41653 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL288663 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL288891 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL38548 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL288889 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL416425 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL38625 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL38084 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL37353 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL39251 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL289056 | — | IC50 | = | 183.0 | nM | 6.74 |
| CHEMBL40020 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL289155 | — | IC50 | = | 235.0 | nM | 6.63 |
| CHEMBL39136 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL41970 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL39931 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL41266 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL289357 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL38648 | — | IC50 | = | 430.0 | nM | 6.37 |