Assay Detail
Binding
CHEMBL731498
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Inhibition of mitogen-activated protein kinase p38 alpha 2
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
1-Phenyl-5-pyrazolyl ureas: potent and selective p38 kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 7.18 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL64041 | — | — | 1 | 7.96 |
| CHEMBL64040 | — | — | 1 | 7.89 |
| CHEMBL10 | SB-203580 | — | 1 | 7.70 |
| CHEMBL62943 | — | — | 1 | 7.54 |
| CHEMBL63071 | — | — | 1 | 7.52 |
| CHEMBL418657 | — | — | 1 | 7.50 |
| CHEMBL291835 | — | — | 1 | 7.48 |
| CHEMBL64031 | — | — | 1 | 7.46 |
| CHEMBL441793 | — | — | 1 | 7.41 |
| CHEMBL65073 | — | — | 1 | 7.38 |
| CHEMBL303798 | — | — | 1 | 7.37 |
| CHEMBL62459 | — | — | 1 | 7.36 |
| CHEMBL291826 | — | — | 1 | 7.28 |
| CHEMBL41653 | — | — | 1 | 7.28 |
| CHEMBL64192 | — | — | 1 | 7.25 |
| CHEMBL304227 | — | — | 1 | 7.06 |
| CHEMBL304256 | — | — | 1 | 6.98 |
| CHEMBL64820 | — | — | 1 | 6.96 |
| CHEMBL64432 | — | — | 1 | 6.92 |
| CHEMBL62927 | — | — | 1 | 6.89 |
| CHEMBL303562 | — | — | 1 | 6.89 |
| CHEMBL61846 | — | — | 1 | 6.75 |
| CHEMBL61735 | — | — | 1 | 6.60 |
| CHEMBL61326 | — | — | 1 | 6.54 |
| CHEMBL62859 | — | — | 1 | 6.49 |
| CHEMBL293644 | — | — | 1 | 6.10 |
| CHEMBL59876 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL64041 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL64040 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL10 | SB-203580 | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL62943 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL63071 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL418657 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL291835 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL64031 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL441793 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL65073 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL303798 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL62459 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL291826 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL41653 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL64192 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL304227 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL304256 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL64820 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL64432 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL62927 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL303562 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL61846 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL61735 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL61326 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL62859 | — | IC50 | = | 325.0 | nM | 6.49 |
| CHEMBL293644 | — | IC50 | = | 797.0 | nM | 6.10 |
| CHEMBL59876 | — | IC50 | > | 500.0 | nM | - |