Assay Detail
Functional
CHEMBL733377
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability for prevention of GSH depletion was measured in mouse
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel lipoic acid analogues that inhibit nitric oxide synthase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 4.56 | 4.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34792 | — | — | 1 | 4.92 |
| CHEMBL33692 | — | — | 1 | 4.91 |
| CHEMBL32644 | — | — | 1 | 4.43 |
| CHEMBL32450 | — | — | 1 | 4.33 |
| CHEMBL33601 | — | — | 1 | 4.19 |
| CHEMBL134342 | THIOCTIC ACID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34792 | — | EC50 | = | 11900.0 | nM | 4.92 |
| CHEMBL33692 | — | EC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL32644 | — | EC50 | = | 37100.0 | nM | 4.43 |
| CHEMBL32450 | — | EC50 | = | 46900.0 | nM | 4.33 |
| CHEMBL33601 | — | EC50 | = | 64800.0 | nM | 4.19 |
| CHEMBL134342 | THIOCTIC ACID | EC50 | = | 121600.0 | nM | - |