Assay Detail
Functional
CHEMBL733379
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to induce mouse macrophage IL-6 assay in peritoneal exudate cells harvested by gavage from C57BI/6 mice.
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Novel N-arylpyrazolo[3,2-c]-based ligands for the glucocorticoid receptor: receptor binding and in vivo activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 22 | 7.64 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL311662 | — | — | 1 | 8.85 |
| CHEMBL82546 | — | — | 1 | 8.43 |
| CHEMBL310570 | — | — | 1 | 8.28 |
| CHEMBL131 | PREDNISOLONE | 4.0 | 1 | 8.24 |
| CHEMBL79335 | — | — | 1 | 8.24 |
| CHEMBL311034 | — | — | 1 | 8.19 |
| CHEMBL312041 | — | — | 1 | 7.82 |
| CHEMBL313062 | — | — | 1 | 7.82 |
| CHEMBL313400 | — | — | 1 | 7.69 |
| CHEMBL79807 | — | — | 1 | 7.67 |
| CHEMBL310420 | — | — | 1 | 7.61 |
| CHEMBL312399 | — | — | 1 | 7.58 |
| CHEMBL309243 | — | — | 1 | 7.44 |
| CHEMBL419479 | — | — | 1 | 7.38 |
| CHEMBL83110 | — | — | 1 | 7.26 |
| CHEMBL310365 | — | — | 1 | 7.24 |
| CHEMBL81111 | — | — | 1 | 7.22 |
| CHEMBL79378 | — | — | 1 | 7.18 |
| CHEMBL81397 | — | — | 1 | 7.11 |
| CHEMBL440877 | — | — | 1 | 7.06 |
| CHEMBL81591 | — | — | 1 | 6.96 |
| CHEMBL309909 | — | — | 1 | 6.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL311662 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL82546 | — | EC50 | = | 3.7 | nM | 8.43 |
| CHEMBL310570 | — | EC50 | = | 5.2 | nM | 8.28 |
| CHEMBL131 | PREDNISOLONE | EC50 | = | 5.7 | nM | 8.24 |
| CHEMBL79335 | — | EC50 | = | 5.7 | nM | 8.24 |
| CHEMBL311034 | — | EC50 | = | 6.5 | nM | 8.19 |
| CHEMBL312041 | — | EC50 | = | 15.1 | nM | 7.82 |
| CHEMBL313062 | — | EC50 | = | 15.2 | nM | 7.82 |
| CHEMBL313400 | — | EC50 | = | 20.5 | nM | 7.69 |
| CHEMBL79807 | — | EC50 | = | 21.6 | nM | 7.67 |
| CHEMBL310420 | — | EC50 | = | 24.7 | nM | 7.61 |
| CHEMBL312399 | — | EC50 | = | 26.3 | nM | 7.58 |
| CHEMBL309243 | — | EC50 | = | 36.2 | nM | 7.44 |
| CHEMBL419479 | — | EC50 | = | 41.5 | nM | 7.38 |
| CHEMBL83110 | — | EC50 | = | 54.3 | nM | 7.26 |
| CHEMBL310365 | — | EC50 | = | 57.4 | nM | 7.24 |
| CHEMBL81111 | — | EC50 | = | 60.1 | nM | 7.22 |
| CHEMBL79378 | — | EC50 | = | 66.6 | nM | 7.18 |
| CHEMBL81397 | — | EC50 | = | 77.2 | nM | 7.11 |
| CHEMBL440877 | — | EC50 | = | 86.5 | nM | 7.06 |
| CHEMBL81591 | — | EC50 | = | 110.8 | nM | 6.96 |
| CHEMBL309909 | — | EC50 | = | 178.6 | nM | 6.75 |