Assay Detail
Binding
CHEMBL734081
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Inhibitory activity against Mitogen-activated protein kinase p38
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Novel and potent transforming growth factor beta type I receptor kinase domain inhibitor: 7-amino 4-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)-quinolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.49 | 7.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL120587 | — | — | 1 | 7.23 |
| CHEMBL332344 | — | — | 1 | 6.36 |
| CHEMBL122583 | — | — | 1 | 6.21 |
| CHEMBL119976 | — | — | 1 | 6.17 |
| CHEMBL119936 | — | — | 1 | 5.80 |
| CHEMBL121554 | — | — | 1 | 5.75 |
| CHEMBL330814 | — | — | 1 | 5.37 |
| CHEMBL120211 | — | — | 1 | 5.34 |
| CHEMBL121795 | — | — | 1 | 5.10 |
| CHEMBL331703 | — | — | 1 | 5.01 |
| CHEMBL325405 | — | — | 1 | 4.96 |
| CHEMBL120245 | — | — | 1 | 4.82 |
| CHEMBL118928 | — | — | 1 | 4.51 |
| CHEMBL261454 | — | — | 1 | 4.29 |
| CHEMBL122414 | — | — | 1 | - |
| CHEMBL122524 | — | — | 1 | - |
| CHEMBL120907 | — | — | 1 | - |
| CHEMBL333798 | — | — | 1 | - |
| CHEMBL121790 | — | — | 1 | - |
| CHEMBL118339 | — | — | 1 | - |
| CHEMBL120718 | — | — | 1 | - |
| CHEMBL120799 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL120587 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL332344 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL122583 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL119976 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL119936 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL121554 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL330814 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL120211 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL121795 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL331703 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL325405 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL120245 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL118928 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL261454 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL122414 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL122524 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL120907 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL333798 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL121790 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL118339 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL120718 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL120799 | — | IC50 | > | 20000.0 | nM | - |