Assay Detail
Functional
CHEMBL734097
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In vivo 5-Lipoxygenase inhibitory activity by using mouse zymosan peritonitis model
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Benzothiazole hydroxy ureas as inhibitors of 5-lipoxygenase: use of the hydroxyurea moiety as a replacement for hydroxamic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 4.72 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL93 | ZILEUTON | 4.0 | 1 | 5.80 |
| CHEMBL274642 | BW-755C | — | 1 | 5.07 |
| CHEMBL419745 | — | — | 1 | 4.64 |
| CHEMBL320274 | — | — | 1 | 4.64 |
| CHEMBL320329 | — | — | 1 | 4.39 |
| CHEMBL316040 | TEPOXALIN | 2.0 | 1 | 4.35 |
| CHEMBL110513 | — | — | 1 | 4.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL93 | ZILEUTON | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL274642 | BW-755C | EC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL419745 | — | EC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL320274 | — | EC50 | = | 23100.0 | nM | 4.64 |
| CHEMBL320329 | — | EC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL316040 | TEPOXALIN | EC50 | = | 44500.0 | nM | 4.35 |
| CHEMBL110513 | — | EC50 | = | 65900.0 | nM | 4.18 |