Assay Detail

CHEMBL735752

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Functional

Irreversible antagonistic potency in mouse vas deferens (MVD)

ChEMBL ↗

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Target

Mus musculus (CHEMBL375) ↗

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Primary target Mus musculus

CHEMBL375

Anchored from Assay target.

Protein identity Mus musculus

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Mus musculus
Tissue	Vas deferens
Confidence	1 — Organism
Curated By	Intermediate

Target

Mus musculus (CHEMBL375) ↗

Type	ORGANISM
Organism	Mus musculus

Publication

Importance of C-6 chirality in conferring irreversible opioid antagonism to naltrexone-derived affinity labels.

Sayre LM, Larson DL, Fries DS, Takemori AE, Portoghese PS.
J Med Chem (1983) 26 : 1229 -1235
PubMed 6310111 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	7.65	9.45

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL340032	DADLE	—	1	9.45
CHEMBL70	MORPHINE	4.0	1	5.85

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL340032	DADLE	IC50	=	0.357	nM	9.45
CHEMBL70	MORPHINE	IC50	=	1420.0	nM	5.85