Assay Detail
Functional
CHEMBL737122
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The ability of compound to inhibit the transformation of osteoblast-like cells originally derived from mouse calvaria, into osteoclasts by OCFORM assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Nonpeptide alpha(v)beta(3) antagonists. Part 2: constrained glycyl amides derived from the RGD tripeptide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.86 | 7.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL300008 | — | — | 1 | 7.21 |
| CHEMBL329081 | — | — | 1 | 7.10 |
| CHEMBL95987 | — | — | 1 | 6.82 |
| CHEMBL416669 | — | — | 1 | 6.32 |
| CHEMBL99287 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL300008 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL329081 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL95987 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL416669 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL99287 | — | IC50 | > | 1000.0 | nM | - |