Assay Detail
Functional
CHEMBL737127
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in vitro inhibition of electrically evoked contractions of MVD (Mouse vas deferens)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Pseudoproline-containing analogues of morphiceptin and endomorphin-2: evidence for a cis Tyr-Pro amide bond in the bioactive conformation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.33 | 7.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL35838 | [LEU5]ENKEPHALIN | — | 1 | 7.94 |
| CHEMBL333357 | ENDOMORPHIN 2 | — | 1 | 7.82 |
| CHEMBL2370620 | — | — | 1 | 6.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL35838 | [LEU5]ENKEPHALIN | IC50 | = | 11.4 | nM | 7.94 |
| CHEMBL333357 | ENDOMORPHIN 2 | IC50 | = | 15.3 | nM | 7.82 |
| CHEMBL2370620 | — | IC50 | = | 594.0 | nM | 6.23 |