Assay Detail
Functional
CHEMBL737750
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In vitro ability to inhibit mouse allogenic mixed leukocyte response (MLR)
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis, and structure-activity relationships of 2-substituted-2-amino-1,3-propanediols: Discovery of a novel immunosuppressant, FTY720
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.64 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL139031 | — | — | 1 | 8.54 |
| CHEMBL141579 | — | — | 1 | 8.23 |
| CHEMBL314854 | FINGOLIMOD | 4.0 | 1 | 8.21 |
| CHEMBL169107 | — | — | 1 | 8.07 |
| CHEMBL168288 | — | — | 1 | 7.89 |
| CHEMBL100953 | — | — | 1 | 7.72 |
| CHEMBL169228 | — | — | 1 | 7.50 |
| CHEMBL354050 | — | — | 1 | 7.27 |
| CHEMBL171166 | — | — | 1 | 7.16 |
| CHEMBL169261 | — | — | 1 | 7.00 |
| CHEMBL168535 | — | — | 1 | 6.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL139031 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL141579 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL314854 | FINGOLIMOD | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL169107 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL168288 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL100953 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL169228 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL354050 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL171166 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL169261 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL168535 | — | IC50 | = | 350.0 | nM | 6.46 |