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Assay Detail

CHEMBL737757

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibitory activity on IFN-gamma-induced nitric oxide production in mouse macrophage at a concentration of 0.1-40 uM
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Confidence 1 — Organism
Curated By Expert

Target

Mus musculus (CHEMBL375)
Type ORGANISM
Organism Mus musculus

Publication

New enone derivatives of oleanolic acid and ursolic acid as inhibitors of nitric oxide production in mouse macrophages
Honda T, Finlay HJ, Gribble GW, Suh N, Sporn MB
Bioorg Med Chem Lett (1997) 7 : 1623 -1628
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 5.02 6.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1765578 1 6.05
CHEMBL42704 1 5.75
CHEMBL433460 1 5.58
CHEMBL296070 1 5.48
CHEMBL44527 1 5.29
CHEMBL416274 1 5.28
CHEMBL43043 1 5.22
CHEMBL46459 1 5.07
CHEMBL290070 1 5.01
CHEMBL42755 1 4.75
CHEMBL42239 1 4.58
CHEMBL44192 1 4.52
CHEMBL42286 1 4.45
CHEMBL470029 OLEANONIC ACID 1 4.43
CHEMBL168 OLEANOLIC_ACID 1 4.40
CHEMBL446352 1 4.40

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1765578 IC50 = 900.0 nM 6.05
CHEMBL42704 IC50 = 1800.0 nM 5.75
CHEMBL433460 IC50 = 2600.0 nM 5.58
CHEMBL296070 IC50 = 3300.0 nM 5.48
CHEMBL44527 IC50 = 5100.0 nM 5.29
CHEMBL416274 IC50 = 5200.0 nM 5.28
CHEMBL43043 IC50 = 6000.0 nM 5.22
CHEMBL46459 IC50 = 8500.0 nM 5.07
CHEMBL290070 IC50 = 9700.0 nM 5.01
CHEMBL42755 IC50 = 17600.0 nM 4.75
CHEMBL42239 IC50 = 26500.0 nM 4.58
CHEMBL44192 IC50 = 30000.0 nM 4.52
CHEMBL42286 IC50 = 35500.0 nM 4.45
CHEMBL470029 OLEANONIC ACID IC50 = 37100.0 nM 4.43
CHEMBL168 OLEANOLIC_ACID IC50 = 40000.0 nM 4.40
CHEMBL446352 IC50 = 40000.0 nM 4.40