Assay Detail
Functional
CHEMBL737773
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Electrophysiological responses in closed channel block to NMDA were recorded in 13-day old mouse cortical neuronal cultures.
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Identification, synthesis, and characterization of a unique class of N-methyl-D-aspartate antagonists. The 6,11-ethanobenzo[b]quinolizinium cation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.24 | 8.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL344151 | DIZOCILPINE MALEATE | -1.0 | 1 | 8.24 |
| CHEMBL52124 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL344151 | DIZOCILPINE MALEATE | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL52124 | — | IC50 | > | 100.0 | nM | - |