Assay Detail
Functional
CHEMBL738328
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Ability to inhibit depolarizations induced by NMDA in mouse cortical wedge preparations.
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
7-Chloro-4,5-dihydro-8-(1,2,4-triazol-4-yl)-4-oxo-1,2,4-triazolo[1, 5-a]quinoxaline-2- carboxylates as novel highly selective AMPA receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.45 | 5.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50267 | — | — | 1 | 5.33 |
| CHEMBL267276 | TQX-173 | — | 1 | 4.34 |
| CHEMBL310014 | — | — | 1 | 4.12 |
| CHEMBL314956 | — | — | 1 | 4.00 |
| CHEMBL105895 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50267 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL267276 | TQX-173 | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL310014 | — | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL314956 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL105895 | — | IC50 | > | 100000.0 | nM | - |