Assay Detail
Functional
CHEMBL738336
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Compound concentration that causes inhibition of [3H]-acetyl choline release by 50% was determined using reserpine-alpha MPT treated mice striatal slices
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Dopaminergic agonists: comparative actions of amine and sulfonium analogues of dopamine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.75 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL26736 | — | — | 1 | 8.00 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 5.00 |
| CHEMBL28278 | — | — | 1 | 5.00 |
| CHEMBL347228 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL26736 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL59 | DOPAMINE | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL28278 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL347228 | — | IC50 | = | 10000.0 | nM | 5.00 |