Assay Detail
Functional
CHEMBL738701
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Inhibitory effect was measured on mouse vas deferens
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Tissue | Vas deferens |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Pseudopeptide analogues of substance P and leucine enkephalinamide containing the psi (CH2O) modification: synthesis and biological activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.83 | 9.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL312346 | — | — | 1 | 9.27 |
| CHEMBL311677 | — | — | 1 | 9.12 |
| CHEMBL595972 | — | — | 1 | 8.38 |
| CHEMBL311030 | — | — | 1 | 7.93 |
| CHEMBL38874 | DAMGO | — | 1 | 7.29 |
| CHEMBL312194 | — | — | 1 | 7.04 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 5.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL312346 | — | IC50 | = | 0.54 | nM | 9.27 |
| CHEMBL311677 | — | IC50 | = | 0.76 | nM | 9.12 |
| CHEMBL595972 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL311030 | — | IC50 | = | 11.8 | nM | 7.93 |
| CHEMBL38874 | DAMGO | IC50 | = | 51.5 | nM | 7.29 |
| CHEMBL312194 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL70 | MORPHINE | IC50 | = | 1722.0 | nM | 5.76 |