Assay Detail
Functional
CHEMBL738703
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Inhibitory potency evaluated against electrically evoked contractions of mouse vas deferens
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Tissue | Vas deferens |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Development of conformationally constrained linear peptides exhibiting a high affinity and pronounced selectivity for delta opioid receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 8.72 | 9.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL55734 | — | — | 1 | 9.82 |
| CHEMBL57776 | — | — | 1 | 9.46 |
| CHEMBL124283 | — | — | 1 | 9.40 |
| CHEMBL56933 | — | — | 1 | 9.22 |
| CHEMBL55498 | — | — | 1 | 9.12 |
| CHEMBL299029 | — | — | 1 | 9.08 |
| CHEMBL298972 | — | — | 1 | 8.97 |
| CHEMBL31421 | — | — | 1 | 8.60 |
| CHEMBL301702 | — | — | 1 | 8.47 |
| CHEMBL13786 | — | — | 1 | 7.89 |
| CHEMBL56394 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL55734 | — | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL57776 | — | IC50 | = | 0.35 | nM | 9.46 |
| CHEMBL124283 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL56933 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL55498 | — | IC50 | = | 0.75 | nM | 9.12 |
| CHEMBL299029 | — | IC50 | = | 0.84 | nM | 9.08 |
| CHEMBL298972 | — | IC50 | = | 1.07 | nM | 8.97 |
| CHEMBL31421 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL301702 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL13786 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL56394 | — | IC50 | = | 1194.0 | nM | 5.92 |