Assay Detail
Functional
CHEMBL739440
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for inhibition of L1210 cell growth in mouse.
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Folate-based inhibitors of thymidylate synthase: synthesis and antitumor activity of gamma-linked sterically hindered dipeptide analogues of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.30 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL35926 | — | — | 1 | 7.16 |
| CHEMBL30179 | — | — | 1 | 6.96 |
| CHEMBL288666 | — | — | 1 | 6.80 |
| CHEMBL291084 | — | — | 1 | 6.66 |
| CHEMBL264609 | — | — | 1 | 6.64 |
| CHEMBL288615 | — | — | 1 | 6.62 |
| CHEMBL37106 | — | — | 1 | 6.47 |
| CHEMBL36721 | — | — | 1 | 6.39 |
| CHEMBL36433 | — | — | 1 | 6.19 |
| CHEMBL289749 | — | — | 1 | 6.14 |
| CHEMBL35941 | — | — | 1 | 5.96 |
| CHEMBL287693 | — | — | 1 | 5.85 |
| CHEMBL36426 | — | — | 1 | 5.62 |
| CHEMBL34857 | — | — | 1 | 5.60 |
| CHEMBL284613 | — | — | 1 | 5.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL35926 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL30179 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL288666 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL291084 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL264609 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL288615 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL37106 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL36721 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL36433 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL289749 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL35941 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL287693 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL36426 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL34857 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL284613 | — | IC50 | = | 3100.0 | nM | 5.51 |