Assay Detail
Functional
CHEMBL739442
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for inhibition of L1210:R D1694 cell growth in mouse.
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Folate-based inhibitors of thymidylate synthase: synthesis and antitumor activity of gamma-linked sterically hindered dipeptide analogues of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.60 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL35926 | — | — | 1 | 6.66 |
| CHEMBL30179 | — | — | 1 | 6.24 |
| CHEMBL287693 | — | — | 1 | 5.92 |
| CHEMBL37106 | — | — | 1 | 5.85 |
| CHEMBL291084 | — | — | 1 | 5.70 |
| CHEMBL288615 | — | — | 1 | 5.66 |
| CHEMBL289749 | — | — | 1 | 5.58 |
| CHEMBL264609 | — | — | 1 | 5.58 |
| CHEMBL288666 | — | — | 1 | 5.57 |
| CHEMBL36721 | — | — | 1 | 5.47 |
| CHEMBL36433 | — | — | 1 | 5.40 |
| CHEMBL34857 | — | — | 1 | 5.15 |
| CHEMBL35941 | — | — | 1 | 5.13 |
| CHEMBL36426 | — | — | 1 | 5.04 |
| CHEMBL284613 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL35926 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL30179 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL287693 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL37106 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL291084 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL288615 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL289749 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL264609 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL288666 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL36721 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL36433 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL34857 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL35941 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL36426 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL284613 | — | IC50 | = | 10000.0 | nM | 5.00 |