Assay Detail
Functional
CHEMBL740144
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In vitro inhibition of electrically evoked contractions of MVD (Mouse vas deferens)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Pseudoproline-containing analogues of morphiceptin and endomorphin-2: evidence for a cis Tyr-Pro amide bond in the bioactive conformation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.36 | 6.86 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL338198 | — | — | 1 | 6.86 |
| CHEMBL339725 | — | — | 1 | 6.82 |
| CHEMBL126611 | — | — | 1 | 6.72 |
| CHEMBL339724 | — | — | 1 | 6.22 |
| CHEMBL338113 | — | — | 1 | 6.07 |
| CHEMBL129323 | — | — | 1 | 5.99 |
| CHEMBL126794 | — | — | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL338198 | — | IC50 | = | 138.0 | nM | 6.86 |
| CHEMBL339725 | — | IC50 | = | 151.0 | nM | 6.82 |
| CHEMBL126611 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL339724 | — | IC50 | = | 606.0 | nM | 6.22 |
| CHEMBL338113 | — | IC50 | = | 851.0 | nM | 6.07 |
| CHEMBL129323 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL126794 | — | IC50 | = | 1420.0 | nM | 5.85 |