Assay Detail
Functional
CHEMBL740153
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In vitro inhibitory activity against mouse mixed lymphocyte reaction (MLR)
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Pyrazole bioisosteres of leflunomide as B-cell immunosuppressants for xenotransplantation and chronic rejection: scope and limitations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.32 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL160 | CYCLOSPORINE | 4.0 | 1 | 8.22 |
| CHEMBL118395 | — | — | 1 | 6.35 |
| CHEMBL334317 | — | — | 1 | 5.68 |
| CHEMBL118489 | — | — | 1 | 5.54 |
| CHEMBL118468 | — | — | 1 | 5.51 |
| CHEMBL118168 | — | — | 1 | 5.47 |
| CHEMBL118645 | — | — | 1 | 5.44 |
| CHEMBL119193 | — | — | 1 | 5.43 |
| CHEMBL333344 | — | — | 1 | 5.37 |
| CHEMBL118586 | — | — | 1 | 5.28 |
| CHEMBL119801 | — | — | 1 | 5.22 |
| CHEMBL332480 | — | — | 1 | 5.17 |
| CHEMBL960 | LEFLUNOMIDE | 4.0 | 1 | 5.13 |
| CHEMBL333404 | — | — | 1 | 5.13 |
| CHEMBL120640 | — | — | 1 | 5.12 |
| CHEMBL334117 | — | — | 1 | 5.12 |
| CHEMBL418870 | — | — | 1 | 5.07 |
| CHEMBL118499 | — | — | 1 | 4.79 |
| CHEMBL116206 | — | — | 1 | 4.78 |
| CHEMBL116946 | — | — | 1 | 4.73 |
| CHEMBL432427 | — | — | 1 | 4.69 |
| CHEMBL119780 | — | — | 1 | 4.63 |
| CHEMBL331399 | — | — | 1 | 4.39 |
| CHEMBL119697 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL160 | CYCLOSPORINE | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL118395 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL334317 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL118489 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL118468 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL118168 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL118645 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL119193 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL333344 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL118586 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL119801 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL332480 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL960 | LEFLUNOMIDE | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL333404 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL120640 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL334117 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL418870 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL118499 | — | IC50 | = | 16100.0 | nM | 4.79 |
| CHEMBL116206 | — | IC50 | = | 16500.0 | nM | 4.78 |
| CHEMBL116946 | — | IC50 | = | 18700.0 | nM | 4.73 |
| CHEMBL432427 | — | IC50 | = | 20300.0 | nM | 4.69 |
| CHEMBL119780 | — | IC50 | = | 23600.0 | nM | 4.63 |
| CHEMBL331399 | — | IC50 | = | 40500.0 | nM | 4.39 |
| CHEMBL119697 | — | IC50 | > | 50000.0 | nM | - |