Assay Detail
Functional
CHEMBL740155
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory concentration against electrically induced twitches in mouse vas deferens
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Development of potent bifunctional endomorphin-2 analogues with mixed mu-/delta-opioid agonist and delta-opioid antagonist properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.16 | 9.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL334147 | — | — | 1 | 9.21 |
| CHEMBL331325 | — | — | 1 | 8.73 |
| CHEMBL339417 | — | — | 1 | 8.26 |
| CHEMBL120758 | — | — | 1 | 6.95 |
| CHEMBL333357 | ENDOMORPHIN 2 | — | 1 | 6.46 |
| CHEMBL333350 | — | — | 1 | 5.53 |
| CHEMBL409907 | — | — | 1 | 5.00 |
| CHEMBL332196 | — | — | 1 | - |
| CHEMBL433643 | — | — | 1 | - |
| CHEMBL419591 | — | — | 1 | - |
| CHEMBL120091 | — | — | 1 | - |
| CHEMBL331255 | — | — | 1 | - |
| CHEMBL332371 | — | — | 1 | - |
| CHEMBL118942 | — | — | 1 | - |
| CHEMBL327036 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL334147 | — | IC50 | = | 0.616 | nM | 9.21 |
| CHEMBL331325 | — | IC50 | = | 1.87 | nM | 8.73 |
| CHEMBL339417 | — | IC50 | = | 5.47 | nM | 8.26 |
| CHEMBL120758 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL333357 | ENDOMORPHIN 2 | IC50 | = | 344.0 | nM | 6.46 |
| CHEMBL333350 | — | IC50 | = | 2981.0 | nM | 5.53 |
| CHEMBL409907 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL332196 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL433643 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL419591 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL120091 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL331255 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL332371 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL118942 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL327036 | — | IC50 | > | 10000.0 | nM | - |