Assay Detail
Functional
CHEMBL740156
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In vitro neuroprotective efficacy determined to protect cultured mouse cortical neurons from an excitotoxic exposure to NMDA
11
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Identification, synthesis, and characterization of a unique class of N-methyl-D-aspartate antagonists. The 6,11-ethanobenzo[b]quinolizinium cation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.61 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL139199 | — | — | 1 | 7.66 |
| CHEMBL52124 | — | — | 2 | 7.58 |
| CHEMBL436008 | — | — | 1 | 7.50 |
| CHEMBL342885 | — | — | 1 | 7.07 |
| CHEMBL139641 | — | — | 1 | 6.80 |
| CHEMBL138943 | — | — | 1 | 6.76 |
| CHEMBL138837 | — | — | 2 | 6.09 |
| CHEMBL342181 | — | — | 1 | 5.98 |
| CHEMBL140343 | — | — | 1 | 4.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL139199 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL52124 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL436008 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL52124 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL342885 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL139641 | — | IC50 | = | 157.0 | nM | 6.80 |
| CHEMBL138943 | — | IC50 | = | 173.0 | nM | 6.76 |
| CHEMBL138837 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL342181 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL138837 | — | IC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL140343 | — | IC50 | = | 95000.0 | nM | 4.02 |