Assay Detail
Functional
CHEMBL740157
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Chondrogenesis in day 11 embryonic limb bud cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and structure-activity relationships of retinoid X receptor selective diaryl sulfide analogs of retinoic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.40 | 10.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL275311 | — | — | 1 | 10.22 |
| CHEMBL38 | TRETINOIN | 4.0 | 1 | 7.51 |
| CHEMBL705 | ALITRETINOIN | 4.0 | 1 | 7.24 |
| CHEMBL118693 | — | — | 1 | 6.04 |
| CHEMBL116886 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL275311 | — | IC50 | = | 0.06 | nM | 10.22 |
| CHEMBL38 | TRETINOIN | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL705 | ALITRETINOIN | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL118693 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL116886 | — | IC50 | = | 1000.0 | nM | 6.00 |