Assay Detail
Functional
CHEMBL740158
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Inhibition of bone mineralization in the calvaria assay of mouse
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Highly potent geminal bisphosphonates. From pamidronate disodium (Aredia) to zoledronic acid (Zometa).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.90 | 5.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54537 | — | — | 1 | 5.40 |
| CHEMBL101886 | — | — | 1 | 5.05 |
| CHEMBL100335 | — | — | 1 | 4.82 |
| CHEMBL870 | ALENDRONIC ACID | 4.0 | 1 | 4.70 |
| CHEMBL301244 | — | — | 1 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54537 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL101886 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL100335 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL870 | ALENDRONIC ACID | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL301244 | — | IC50 | = | 30000.0 | nM | 4.52 |