Assay Detail
Functional
CHEMBL740159
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of bone resorption in the calvaria assay of mouse
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Highly potent geminal bisphosphonates. From pamidronate disodium (Aredia) to zoledronic acid (Zometa).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.50 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4303669 | ZOLEDRONIC ACID | 4.0 | 1 | 8.70 |
| CHEMBL301244 | — | — | 1 | 7.70 |
| CHEMBL100335 | — | — | 1 | 7.40 |
| CHEMBL101886 | — | — | 1 | 7.40 |
| CHEMBL54537 | — | — | 1 | 7.30 |
| CHEMBL870 | ALENDRONIC ACID | 4.0 | 1 | 7.30 |
| CHEMBL834 | PAMIDRONIC ACID | 4.0 | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4303669 | ZOLEDRONIC ACID | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL301244 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL100335 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL101886 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL54537 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL870 | ALENDRONIC ACID | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL834 | PAMIDRONIC ACID | IC50 | = | 200.0 | nM | 6.70 |