Assay Detail
Functional
CHEMBL740160
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Inhibition of growth in L1210 murine leukemia cells in culture expressed as IC50 (nM)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and antitumor activity of 10-propargyl-10-deazaaminopterin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.79 | 8.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10515 | — | — | 1 | 8.87 |
| CHEMBL296373 | EDATREXATE | 2.0 | 1 | 8.84 |
| CHEMBL293263 | — | — | 1 | 8.74 |
| CHEMBL306438 | — | — | 1 | 8.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10515 | — | IC50 | = | 1.34 | nM | 8.87 |
| CHEMBL296373 | EDATREXATE | IC50 | = | 1.44 | nM | 8.84 |
| CHEMBL293263 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL306438 | — | IC50 | = | 2.0 | nM | 8.70 |