Assay Detail
Binding
CHEMBL740207
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Tested in vitro for norepinephrine (NE) neuronal uptake inhibition
29
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sodium-dependent noradrenaline transporter (CHEMBL2370) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Pyrroloisoquinoline antidepressants. 3. A focus on serotonin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 29 | 7.79 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL35184 | — | — | 1 | 9.22 |
| CHEMBL285506 | — | — | 1 | 9.17 |
| CHEMBL330666 | — | — | 1 | 9.03 |
| CHEMBL94535 | — | — | 1 | 8.80 |
| CHEMBL327790 | — | — | 3 | 8.74 |
| CHEMBL96362 | — | — | 1 | 8.49 |
| CHEMBL94711 | — | — | 1 | 8.48 |
| CHEMBL94665 | — | — | 1 | 8.35 |
| CHEMBL539803 | — | — | 1 | 8.22 |
| CHEMBL94738 | — | — | 1 | 7.97 |
| CHEMBL555462 | — | — | 1 | 7.94 |
| CHEMBL11 | IMIPRAMINE | 4.0 | 1 | 7.92 |
| CHEMBL329216 | — | — | 1 | 7.86 |
| CHEMBL555655 | — | — | 1 | 7.79 |
| CHEMBL94508 | — | — | 1 | 7.77 |
| CHEMBL490 | PAROXETINE | 4.0 | 1 | 7.70 |
| CHEMBL554191 | — | — | 1 | 7.64 |
| CHEMBL95153 | — | — | 1 | 7.23 |
| CHEMBL93035 | — | — | 1 | 7.10 |
| CHEMBL41 | FLUOXETINE | 4.0 | 1 | 7.07 |
| CHEMBL328818 | — | — | 1 | 7.04 |
| CHEMBL541308 | — | — | 1 | 7.03 |
| CHEMBL94739 | FEMOXETINE | 2.0 | 1 | 6.92 |
| CHEMBL284305 | — | — | 1 | 6.90 |
| CHEMBL545724 | — | — | 1 | 6.41 |
| CHEMBL96615 | — | — | 1 | 6.14 |
| CHEMBL549 | CITALOPRAM | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL35184 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL285506 | — | Ki | = | 0.68 | nM | 9.17 |
| CHEMBL330666 | — | Ki | = | 0.94 | nM | 9.03 |
| CHEMBL94535 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL327790 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL327790 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL96362 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL94711 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL94665 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL539803 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL94738 | — | Ki | = | 10.6 | nM | 7.97 |
| CHEMBL555462 | — | Ki | = | 11.5 | nM | 7.94 |
| CHEMBL11 | IMIPRAMINE | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL329216 | — | Ki | = | 13.8 | nM | 7.86 |
| CHEMBL555655 | — | Ki | = | 16.2 | nM | 7.79 |
| CHEMBL94508 | — | Ki | = | 17.1 | nM | 7.77 |
| CHEMBL490 | PAROXETINE | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL554191 | — | Ki | = | 23.1 | nM | 7.64 |
| CHEMBL95153 | — | Ki | = | 58.8 | nM | 7.23 |
| CHEMBL93035 | — | Ki | = | 78.7 | nM | 7.10 |
| CHEMBL41 | FLUOXETINE | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL328818 | — | Ki | = | 90.2 | nM | 7.04 |
| CHEMBL541308 | — | Ki | = | 93.8 | nM | 7.03 |
| CHEMBL94739 | FEMOXETINE | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL284305 | — | Ki | = | 127.0 | nM | 6.90 |
| CHEMBL327790 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL545724 | — | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL96615 | — | Ki | = | 723.0 | nM | 6.14 |
| CHEMBL549 | CITALOPRAM | Ki | > | 1000.0 | nM | - |