Assay Detail
Functional
CHEMBL740342
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Concentration required for inhibition of electrically stimulated contraction of mouse vas deferens (in vivo)
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Morpholinoalkylindenes as antinociceptive agents: Novel cannabinoid receptor agonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.22 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL127644 | — | — | 1 | 8.15 |
| CHEMBL123515 | — | — | 1 | 8.10 |
| CHEMBL125199 | — | — | 1 | 7.72 |
| CHEMBL123916 | — | — | 1 | 7.35 |
| CHEMBL129525 | — | — | 1 | 7.10 |
| CHEMBL125462 | — | — | 1 | 7.10 |
| CHEMBL124974 | — | — | 1 | 6.72 |
| CHEMBL126301 | — | — | 1 | 6.46 |
| CHEMBL13178 | PRAVADOLINE | 2.0 | 1 | 6.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL127644 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL123515 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL125199 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL123916 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL129525 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL125462 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL124974 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL126301 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL13178 | PRAVADOLINE | IC50 | = | 530.0 | nM | 6.28 |