Assay Detail
Functional
CHEMBL740960
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of the electrically induced muscle contractions was determined using the mouse vas deferens
23
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
3-(alphaR)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N-alkyl-N-arylbenzamides: potent, non-peptidic agonists of both the micro and delta opioid receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 23 | 8.59 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL25230 | — | — | 1 | 9.70 |
| CHEMBL156440 | — | — | 1 | 9.47 |
| CHEMBL346514 | — | — | 1 | 9.44 |
| CHEMBL345683 | — | — | 1 | 9.33 |
| CHEMBL348585 | — | — | 1 | 9.17 |
| CHEMBL157294 | — | — | 1 | 9.16 |
| CHEMBL155892 | — | — | 2 | 9.10 |
| CHEMBL349120 | — | — | 1 | 9.02 |
| CHEMBL156230 | — | — | 1 | 9.02 |
| CHEMBL157660 | — | — | 1 | 8.98 |
| CHEMBL434075 | — | — | 1 | 8.96 |
| CHEMBL157095 | — | — | 1 | 8.85 |
| CHEMBL346987 | — | — | 1 | 8.85 |
| CHEMBL156584 | — | — | 1 | 8.77 |
| CHEMBL155748 | — | — | 1 | 8.77 |
| CHEMBL345431 | — | — | 1 | 8.64 |
| CHEMBL158205 | — | — | 1 | 8.62 |
| CHEMBL155797 | — | — | 1 | 8.59 |
| CHEMBL422877 | — | — | 1 | 8.25 |
| CHEMBL348415 | — | — | 1 | 8.23 |
| CHEMBL596 | FENTANYL | 4.0 | 1 | 6.31 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 4.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL25230 | — | EC50 | = | 0.2 | nM | 9.70 |
| CHEMBL156440 | — | EC50 | = | 0.34 | nM | 9.47 |
| CHEMBL346514 | — | EC50 | = | 0.36 | nM | 9.44 |
| CHEMBL345683 | — | EC50 | = | 0.47 | nM | 9.33 |
| CHEMBL348585 | — | EC50 | = | 0.68 | nM | 9.17 |
| CHEMBL157294 | — | EC50 | = | 0.69 | nM | 9.16 |
| CHEMBL155892 | — | EC50 | = | 0.79 | nM | 9.10 |
| CHEMBL349120 | — | EC50 | = | 0.96 | nM | 9.02 |
| CHEMBL156230 | — | EC50 | = | 0.95 | nM | 9.02 |
| CHEMBL157660 | — | EC50 | = | 1.05 | nM | 8.98 |
| CHEMBL434075 | — | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL157095 | — | EC50 | = | 1.42 | nM | 8.85 |
| CHEMBL346987 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL156584 | — | EC50 | = | 1.7 | nM | 8.77 |
| CHEMBL155748 | — | EC50 | = | 1.7 | nM | 8.77 |
| CHEMBL345431 | — | EC50 | = | 2.3 | nM | 8.64 |
| CHEMBL158205 | — | EC50 | = | 2.4 | nM | 8.62 |
| CHEMBL155797 | — | EC50 | = | 2.6 | nM | 8.59 |
| CHEMBL422877 | — | EC50 | = | 5.6 | nM | 8.25 |
| CHEMBL348415 | — | EC50 | = | 5.85 | nM | 8.23 |
| CHEMBL155892 | — | EC50 | = | 25.3 | nM | 7.60 |
| CHEMBL596 | FENTANYL | EC50 | = | 490.0 | nM | 6.31 |
| CHEMBL70 | MORPHINE | EC50 | = | 19700.0 | nM | 4.71 |