Assay Detail
Functional
CHEMBL740966
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity expressed as inhibitory concentration against contraction of electrically stimulated mouse vas deferens
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
7-spirobenzocyclohexyl derivatives of naltrexone, oxymorphone, and hydromorphone as selective opioid receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.61 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL399708 | SPIROINDANYLOXYMORPHONE | — | 1 | 7.66 |
| CHEMBL104179 | — | — | 1 | 7.62 |
| CHEMBL318598 | — | — | 1 | 7.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL399708 | SPIROINDANYLOXYMORPHONE | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL104179 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL318598 | — | IC50 | = | 28.0 | nM | 7.55 |