Assay Detail
Functional
CHEMBL740972
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Compound was tested in vitro for inhibition of electrically evoked contractions of the mouse vas deferens
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Tissue | Vas deferens |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Conformational restriction of the phenylalanine residue in a cyclic opioid peptide analogue: effects on receptor selectivity and stereospecificity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.11 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL323024 | — | — | 1 | 8.96 |
| CHEMBL107580 | — | — | 1 | 8.96 |
| CHEMBL325810 | — | — | 1 | 8.26 |
| CHEMBL263021 | — | — | 1 | 7.96 |
| CHEMBL15595 | — | — | 1 | 7.94 |
| CHEMBL321335 | — | — | 1 | 7.46 |
| CHEMBL106849 | — | — | 1 | 7.44 |
| CHEMBL3037875 | — | — | 1 | 6.59 |
| CHEMBL104838 | — | — | 1 | 5.68 |
| CHEMBL3084310 | — | — | 1 | 5.51 |
| CHEMBL105453 | — | — | 1 | 5.38 |
| CHEMBL107906 | — | — | 1 | 5.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL323024 | — | IC50 | = | 1.11 | nM | 8.96 |
| CHEMBL107580 | — | IC50 | = | 1.11 | nM | 8.96 |
| CHEMBL325810 | — | IC50 | = | 5.51 | nM | 8.26 |
| CHEMBL263021 | — | IC50 | = | 10.9 | nM | 7.96 |
| CHEMBL15595 | — | IC50 | = | 11.4 | nM | 7.94 |
| CHEMBL321335 | — | IC50 | = | 34.3 | nM | 7.46 |
| CHEMBL106849 | — | IC50 | = | 36.5 | nM | 7.44 |
| CHEMBL3037875 | — | IC50 | = | 254.0 | nM | 6.59 |
| CHEMBL104838 | — | IC50 | = | 2070.0 | nM | 5.68 |
| CHEMBL3084310 | — | IC50 | = | 3070.0 | nM | 5.51 |
| CHEMBL105453 | — | IC50 | = | 4160.0 | nM | 5.38 |
| CHEMBL107906 | — | IC50 | = | 7310.0 | nM | 5.14 |