Assay Detail
Functional
CHEMBL741592
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Inhibitory activity against LPS stimulated RAW 264.7 macrophages
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Solid-phase synthesis and inhibitory effects of some pyrido[1,2-c]pyrimidine derivatives on leukocyte formations and experimental inflammation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.24 | 8.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7162 | NS-398 | — | 1 | 8.68 |
| CHEMBL7148 | — | — | 1 | 6.40 |
| CHEMBL6743 | — | — | 1 | 5.82 |
| CHEMBL7260 | — | — | 1 | 5.80 |
| CHEMBL269255 | — | — | 1 | 5.77 |
| CHEMBL7248 | — | — | 1 | 5.77 |
| CHEMBL6872 | — | — | 1 | 5.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7162 | NS-398 | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL7148 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL6743 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL7260 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL269255 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL7248 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL6872 | — | IC50 | = | 3500.0 | nM | 5.46 |