Assay Detail
Functional
CHEMBL741869
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In vitro cytotoxicity against murine leukemia P388 cell line.
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | P388 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and evaluation of DNA-targeted spatially separated bis(aniline mustards) as potential alkylating agents with enhanced DNA cross-linking capability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.28 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL79723 | — | — | 1 | 7.22 |
| CHEMBL83806 | — | — | 1 | 6.75 |
| CHEMBL313191 | — | — | 1 | 6.54 |
| CHEMBL314685 | — | — | 1 | 6.26 |
| CHEMBL278918 | — | — | 1 | 6.20 |
| CHEMBL273595 | — | — | 1 | 5.83 |
| CHEMBL515 | CHLORAMBUCIL | 4.0 | 1 | 5.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL79723 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL83806 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL313191 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL314685 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL278918 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL273595 | — | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL515 | CHLORAMBUCIL | IC50 | = | 6800.0 | nM | 5.17 |