Assay Detail
Functional
CHEMBL743373
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Inhibitory concentration against NMDA-induced cell death in cultured mouse cortical neurons
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Discovery of 6,11-ethano-12,12-diaryl-6,11-dihydrobenzo[b]quinolizinium cations, a novel class of N-methyl-D-aspartate antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.23 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL314295 | — | — | 1 | 7.64 |
| CHEMBL329811 | — | — | 1 | 7.52 |
| CHEMBL91445 | — | — | 1 | 7.44 |
| CHEMBL299087 | — | — | 1 | 7.41 |
| CHEMBL90486 | — | — | 1 | 7.35 |
| CHEMBL284237 | DIZOCILPINE | 2.0 | 1 | 7.17 |
| CHEMBL329612 | — | — | 1 | 6.71 |
| CHEMBL91321 | — | — | 1 | 6.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL314295 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL329811 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL91445 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL299087 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL90486 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL284237 | DIZOCILPINE | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL329612 | — | IC50 | = | 197.0 | nM | 6.71 |
| CHEMBL91321 | — | IC50 | = | 271.0 | nM | 6.57 |