Assay Detail
Binding
CHEMBL744020
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against rat muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamine
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Heart |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor M2 (CHEMBL309) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and cholinergic properties of N-aryl-2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethylamino analogs of ranitidine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.38 | 5.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL320291 | — | — | 1 | 5.51 |
| CHEMBL106782 | — | — | 1 | 5.46 |
| CHEMBL107892 | — | — | 1 | 5.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL320291 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL106782 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL107892 | — | IC50 | = | 6800.0 | nM | 5.17 |