Assay Detail
Binding
CHEMBL744059
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Compound was evaluated for displacement of [3H]QNB from human Muscarinic m1 receptor in CHO cells.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
The N4 nitrogen of pirenzepine is responsible for selective binding of the M1 subtype human muscarinic receptor
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.52 | 8.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9967 | PIRENZEPINE | 2.0 | 1 | 8.34 |
| CHEMBL279453 | — | — | 1 | 7.91 |
| CHEMBL611476 | — | — | 1 | 7.08 |
| CHEMBL17045 | OTENZEPAD | 2.0 | 1 | 6.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9967 | PIRENZEPINE | Ki | = | 4.6 | nM | 8.34 |
| CHEMBL279453 | — | Ki | = | 12.4 | nM | 7.91 |
| CHEMBL611476 | — | Ki | = | 82.4 | nM | 7.08 |
| CHEMBL17045 | OTENZEPAD | Ki | = | 179.0 | nM | 6.75 |