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Assay Detail

CHEMBL744065

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Functional
Inhibitory activity against Murine P388 leukemia cells
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type P388
Confidence 1 — Organism
Curated By Expert

Target

P388 (CHEMBL389)
Type CELL-LINE
Organism Mus musculus

Publication

Bis(phenazine-1-carboxamides): structure-activity relationships for a new class of dual topoisomerase I/II-directed anticancer drugs.
Spicer JA, Gamage SA, Rewcastle GW, Finlay GJ, Bridewell DJ, Baguley BC, Denny WA.
J Med Chem (2000) 43 : 1350 -1358
PubMed 10753472 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 24 6.63 8.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL281681 1 8.92
CHEMBL30232 1 7.82
CHEMBL265239 1 7.62
CHEMBL281020 1 7.58
CHEMBL26944 1 7.54
CHEMBL29452 1 7.41
CHEMBL29350 1 7.12
CHEMBL26582 1 7.01
CHEMBL9402 1 6.89
CHEMBL29453 1 6.69
CHEMBL29451 1 6.53
CHEMBL281483 1 6.43
CHEMBL30072 1 6.35
CHEMBL284638 1 6.33
CHEMBL27300 1 6.28
CHEMBL281482 1 6.23
CHEMBL283699 1 6.22
CHEMBL26692 1 6.21
CHEMBL26583 1 6.16
CHEMBL25899 1 6.09
CHEMBL285371 1 5.64
CHEMBL286410 1 5.53
CHEMBL287098 1 5.46
CHEMBL30189 1 5.11

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL281681 IC50 = 1.2 nM 8.92
CHEMBL30232 IC50 = 15.0 nM 7.82
CHEMBL265239 IC50 = 24.0 nM 7.62
CHEMBL281020 IC50 = 26.0 nM 7.58
CHEMBL26944 IC50 = 29.0 nM 7.54
CHEMBL29452 IC50 = 39.0 nM 7.41
CHEMBL29350 IC50 = 75.0 nM 7.12
CHEMBL26582 IC50 = 97.0 nM 7.01
CHEMBL9402 IC50 = 130.0 nM 6.89
CHEMBL29453 IC50 = 204.0 nM 6.69
CHEMBL29451 IC50 = 294.0 nM 6.53
CHEMBL281483 IC50 = 375.0 nM 6.43
CHEMBL30072 IC50 = 450.0 nM 6.35
CHEMBL284638 IC50 = 472.0 nM 6.33
CHEMBL27300 IC50 = 520.0 nM 6.28
CHEMBL281482 IC50 = 584.0 nM 6.23
CHEMBL283699 IC50 = 600.0 nM 6.22
CHEMBL26692 IC50 = 623.0 nM 6.21
CHEMBL26583 IC50 = 690.0 nM 6.16
CHEMBL25899 IC50 = 815.0 nM 6.09
CHEMBL285371 IC50 = 2280.0 nM 5.64
CHEMBL286410 IC50 = 2960.0 nM 5.53
CHEMBL287098 IC50 = 3450.0 nM 5.46
CHEMBL30189 IC50 = 7740.0 nM 5.11