Assay Detail
Binding
CHEMBL744234
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Ability to displace [3H]N-methylscopolamine from Muscarinic acetylcholine receptor M1 expressed in CHO cells.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and In vitro binding affinities of 1-azabicyclic compounds as muscarinic ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 4.67 | 5.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL95907 | — | — | 1 | 5.08 |
| CHEMBL320194 | — | — | 1 | 5.06 |
| CHEMBL95983 | — | — | 1 | 4.94 |
| CHEMBL99310 | — | — | 1 | 4.86 |
| CHEMBL100209 | — | — | 1 | 4.83 |
| CHEMBL97208 | — | — | 1 | 4.78 |
| CHEMBL317931 | — | — | 1 | 4.75 |
| CHEMBL317516 | — | — | 1 | 4.63 |
| CHEMBL7634 | OXOTREMORINE | — | 1 | 4.57 |
| CHEMBL97297 | — | — | 1 | 4.53 |
| CHEMBL97581 | — | — | 1 | 4.49 |
| CHEMBL95518 | — | — | 1 | 4.45 |
| CHEMBL320221 | — | — | 1 | 4.44 |
| CHEMBL274822 | — | — | 1 | 4.39 |
| CHEMBL327626 | — | — | 1 | 4.31 |
| CHEMBL97716 | — | — | 1 | - |
| CHEMBL99244 | — | — | 1 | - |
| CHEMBL7303 | ARECOLINE | -1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL95907 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL320194 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL95983 | — | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL99310 | — | IC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL100209 | — | IC50 | = | 14900.0 | nM | 4.83 |
| CHEMBL97208 | — | IC50 | = | 16700.0 | nM | 4.78 |
| CHEMBL317931 | — | IC50 | = | 17700.0 | nM | 4.75 |
| CHEMBL317516 | — | IC50 | = | 23500.0 | nM | 4.63 |
| CHEMBL7634 | OXOTREMORINE | IC50 | = | 27100.0 | nM | 4.57 |
| CHEMBL97297 | — | IC50 | = | 29500.0 | nM | 4.53 |
| CHEMBL97581 | — | IC50 | = | 32500.0 | nM | 4.49 |
| CHEMBL95518 | — | IC50 | = | 35600.0 | nM | 4.45 |
| CHEMBL320221 | — | IC50 | = | 36300.0 | nM | 4.44 |
| CHEMBL274822 | — | IC50 | = | 40540.0 | nM | 4.39 |
| CHEMBL327626 | — | IC50 | = | 48800.0 | nM | 4.31 |
| CHEMBL97716 | — | IC50 | = | 189500.0 | nM | - |
| CHEMBL99244 | — | IC50 | = | 132700.0 | nM | - |
| CHEMBL7303 | ARECOLINE | IC50 | = | 115500.0 | nM | - |