Assay Detail
Binding
CHEMBL744235
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Ability to displace [3H]oxotremorine from Muscarinic acetylcholine receptor M1 expressed in CHO cells.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and In vitro binding affinities of 1-azabicyclic compounds as muscarinic ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.81 | 8.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7634 | OXOTREMORINE | — | 1 | 8.64 |
| CHEMBL320221 | — | — | 1 | 7.64 |
| CHEMBL100209 | — | — | 1 | 7.36 |
| CHEMBL99310 | — | — | 1 | 7.24 |
| CHEMBL95983 | — | — | 1 | 7.14 |
| CHEMBL327626 | — | — | 1 | 7.10 |
| CHEMBL320194 | — | — | 1 | 7.09 |
| CHEMBL97581 | — | — | 1 | 7.09 |
| CHEMBL7303 | ARECOLINE | -1.0 | 1 | 6.94 |
| CHEMBL274822 | — | — | 1 | 6.88 |
| CHEMBL97208 | — | — | 1 | 6.54 |
| CHEMBL99244 | — | — | 1 | 6.47 |
| CHEMBL95518 | — | — | 1 | 6.44 |
| CHEMBL317931 | — | — | 1 | 6.42 |
| CHEMBL317516 | — | — | 1 | 6.10 |
| CHEMBL95907 | — | — | 1 | 5.92 |
| CHEMBL97297 | — | — | 1 | 5.79 |
| CHEMBL97716 | — | — | 1 | 5.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7634 | OXOTREMORINE | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL320221 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL100209 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL99310 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL95983 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL327626 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL320194 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL97581 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL7303 | ARECOLINE | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL274822 | — | IC50 | = | 131.0 | nM | 6.88 |
| CHEMBL97208 | — | IC50 | = | 287.0 | nM | 6.54 |
| CHEMBL99244 | — | IC50 | = | 341.0 | nM | 6.47 |
| CHEMBL95518 | — | IC50 | = | 362.0 | nM | 6.44 |
| CHEMBL317931 | — | IC50 | = | 385.0 | nM | 6.42 |
| CHEMBL317516 | — | IC50 | = | 795.0 | nM | 6.10 |
| CHEMBL95907 | — | IC50 | = | 1217.0 | nM | 5.92 |
| CHEMBL97297 | — | IC50 | = | 1641.0 | nM | 5.79 |
| CHEMBL97716 | — | IC50 | = | 1860.0 | nM | 5.73 |