Assay Detail
Functional
CHEMBL744373
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In vitro immunosuppressive activity in murine splenic T cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | T-cell |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
C32-O-phenalkyl ether derivatives of the immunosuppressant ascomycin: a tether length study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 8.88 | 9.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL264361 | — | — | 1 | 9.74 |
| CHEMBL425444 | — | — | 1 | 9.57 |
| CHEMBL406186 | — | — | 1 | 9.21 |
| CHEMBL8597 | ASCOMYCIN | — | 1 | 9.16 |
| CHEMBL265767 | — | — | 1 | 9.00 |
| CHEMBL293155 | — | — | 1 | 8.52 |
| CHEMBL216672 | — | — | 1 | 8.46 |
| CHEMBL263032 | — | — | 1 | 8.46 |
| CHEMBL292985 | — | — | 1 | 8.37 |
| CHEMBL262698 | — | — | 1 | 8.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL264361 | — | IC50 | = | 0.18 | nM | 9.74 |
| CHEMBL425444 | — | IC50 | = | 0.27 | nM | 9.57 |
| CHEMBL406186 | — | IC50 | = | 0.61 | nM | 9.21 |
| CHEMBL8597 | ASCOMYCIN | IC50 | = | 0.69 | nM | 9.16 |
| CHEMBL265767 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL293155 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL216672 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL263032 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL292985 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL262698 | — | IC50 | = | 5.4 | nM | 8.27 |